Benjamin G Neel Selected Research

Protein Tyrosine Phosphatases

1/2020	The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis.
12/2018	Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma.
1/2018	Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.
1/2018	Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia.
1/2016	Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.
1/2015	Differential regulation of FGFR3 by PTPN1 and PTPN2.
7/2014	Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2.
3/2014	Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11).
8/2012	Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance.
7/2007	B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.

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Benjamin G Neel Research Topics

Disease

51	Neoplasms (Cancer) 01/2022 - 09/2002
15	Noonan Syndrome (Female Pseudo-Turner Syndrome) 01/2021 - 08/2004
14	Obesity 10/2021 - 04/2002
12	Insulin Resistance 01/2021 - 01/2004
8	Breast Neoplasms (Breast Cancer) 01/2022 - 08/2002
8	Ovarian Neoplasms (Ovarian Cancer) 01/2021 - 02/2012
8	Leukemia 01/2018 - 03/2004
5	Inflammation (Inflammations) 01/2021 - 01/2007
5	Hypersensitivity (Allergy) 09/2014 - 04/2002
4	Inborn Genetic Diseases (Disease, Hereditary) 01/2020 - 09/2005
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018 - 03/2008
4	LEOPARD Syndrome (Syndrome, LEOPARD) 01/2018 - 05/2010
4	Carcinogenesis 01/2016 - 09/2002
3	Type 2 Diabetes Mellitus (MODY) 10/2021 - 01/2005
3	Neuroblastoma 01/2017 - 12/2004
2	Moyamoya Disease (Moya-Moya Disease) 01/2022 - 01/2016
2	Carcinoma (Carcinomatosis) 01/2021 - 03/2008
2	Thrombosis (Thrombus) 12/2019 - 08/2005
2	Hematologic Neoplasms (Hematological Malignancy) 01/2017 - 04/2016
2	Hypertrophy 01/2017 - 07/2005
2	Hypoxia (Hypoxemia) 01/2016 - 01/2012
2	Weight Loss (Weight Reduction) 01/2015 - 09/2014
2	Weight Gain 09/2014 - 11/2011
2	Neurofibromatosis 1 (Neurofibromatosis Type I) 08/2014 - 03/2013
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2013 - 03/2009
2	Body Weight (Weight, Body) 01/2012 - 08/2006
2	Juvenile Myelomonocytic Leukemia 11/2010 - 04/2009
2	Melanoma (Melanoma, Malignant) 09/2010 - 09/2002
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2022
1	Polycythemia (Erythrocytosis) 10/2021
1	Splenomegaly 10/2021
1	Genomic Instability 11/2020
1	Neurodevelopmental Disorders 01/2020
1	Kidney Neoplasms (Kidney Cancer) 11/2019
1	Renal Cell Carcinoma (Grawitz Tumor) 11/2019
1	Leiomyomatosis 11/2019
1	Triple Negative Breast Neoplasms 10/2018
1	Hydrocephalus (Hydrocephaly) 01/2018

Drug/Important Bio-Agent (IBA)

17	Protein Tyrosine PhosphatasesIBA 01/2020 - 04/2002
16	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2002
16	Tyrosine (L-Tyrosine)FDA Link 01/2021 - 08/2002
13	Insulin (Novolin)FDA Link 10/2021 - 04/2002
10	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2020 - 06/2004
9	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2004
9	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 07/2013 - 06/2004
8	Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA 01/2021 - 01/2007
8	LeptinIBA 01/2015 - 04/2002
7	Phosphotransferases (Kinase)IBA 01/2020 - 09/2002
6	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 01/2017 - 06/2004
5	Pharmaceutical PreparationsIBA 01/2022 - 04/2013
5	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 11/2015 - 01/2007
4	DNA (Deoxyribonucleic Acid)IBA 09/2017 - 07/2007
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2015 - 08/2002
3	LigandsIBA 01/2022 - 10/2018
3	Tyrosine Kinase InhibitorsIBA 01/2022 - 08/2015
3	Antineoplastic Agents (Antineoplastics)IBA 01/2018 - 12/2004
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 04/2013
3	CytokinesIBA 01/2017 - 11/2006
3	ErbB Receptors (EGF Receptor)IBA 08/2015 - 01/2003
2	RNA (Ribonucleic Acid)IBA 01/2022 - 09/2015
2	LipidsIBA 01/2021 - 05/2014
2	Phenobarbital (Luminal)FDA Link 11/2020 - 01/2016
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 07/2005
2	Mitogen-Activated Protein KinasesIBA 01/2020 - 03/2008
2	tyrosine receptor (receptor, tyrosine)IBA 01/2020 - 10/2018
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2019 - 01/2011
2	AntibodiesIBA 01/2018 - 07/2007
2	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2018 - 09/2017
2	DioxygenasesIBA 09/2017 - 01/2016
2	PhosphotyrosineIBA 01/2017 - 01/2015
2	Small Interfering RNA (siRNA)IBA 01/2016 - 02/2012
2	GTP Phosphohydrolases (GTPases)IBA 05/2015 - 03/2013
2	Growth Hormone (Somatotropin)IBA 07/2014 - 03/2012
2	Parathyroid Hormone-Related ProteinIBA 07/2013 - 01/2013
2	IntegrinsIBA 03/2013 - 02/2004
2	Insulin ReceptorIBA 01/2012 - 08/2007
2	Sirolimus (Rapamycin)FDA Link 03/2011 - 03/2004
2	Messenger RNA (mRNA)IBA 05/2010 - 08/2002
2	Phosphatidylinositols (Phosphatidylinositol)IBA 07/2005 - 09/2002
1	ATPases Associated with Diverse Cellular ActivitiesIBA 01/2022
1	Leptin ReceptorsIBA 10/2021
1	ruxolitinibIBA 10/2021
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021
1	FollistatinIBA 01/2021
1	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 11/2020
1	DNA Repair EnzymesIBA 11/2020
1	phenothiazineIBA 01/2020
1	IsoenzymesIBA 01/2020
1	CollagenIBA 12/2019
1	Fumarate Hydratase (Fumarase)IBA 11/2019
1	tremelimumabIBA 04/2019
1	PlatinumIBA 01/2019
1	trametinibIBA 10/2018
1	SHP099IBA 10/2018
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 10/2018
1	SH2 Domain-Containing Protein Tyrosine PhosphatasesIBA 09/2018
1	Carboplatin (JM8)FDA LinkGeneric 01/2018

Therapy/Procedure

15	Therapeutics 01/2022 - 12/2004
4	Drug Therapy (Chemotherapy) 01/2021 - 01/2011
3	Immunotherapy 01/2021 - 04/2019